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Updated: Jun 30, 2026

Analysis of Coronary Vessels in Cleared Embryonic Hearts
Published on: December 7, 2016
Great vessel, cardiac chamber, and wall growth patterns in normal children
Insights
This study provides normal echocardiographic measurements for healthy children, establishing reference ranges for cardiac dimensions and function. These pediatric echocardiography data aid in diagnosing and monitoring heart conditions in children.
Area of Science:
- Pediatric Cardiology
- Echocardiography
- Cardiac Physiology
Background:
- Establishing normative echocardiographic data is crucial for accurate pediatric cardiac assessment.
- Variations in cardiac dimensions and function exist across different age groups and body sizes in children.
Purpose of the Study:
- To establish normal echocardiographic measurements for pediatric patients from infancy to adulthood.
- To define reference ranges for valvular motion, cardiac cavity dimensions, great vessel diameters, and ventricular wall thicknesses.
Main Methods:
- Conducted echocardiograms on 205 healthy children using standardized protocols.
- Measured key cardiac parameters including ventricular dimensions, wall thicknesses, great vessel diameters, and valvular motion.
- Grouped data into the 5th, 50th, and 95th percentiles based on body surface area.
Main Results:
- Presented comprehensive echocardiographic measurements stratified by body surface area.
- Developed percentile-based graphs for comparing individual patient measurements to normal standards.
- Provided normative data for left and right ventricular dimensions, septal and free wall thicknesses, and great artery diameters.
Conclusions:
- The established reference ranges facilitate the interpretation of echocardiograms in pediatric populations.
- This study offers a valuable tool for clinicians to assess cardiac health and identify abnormalities in children.
- Normative echocardiographic data are essential for precise diagnosis and management of pediatric cardiovascular diseases.
Abstract:
The purpose of this study was to establish normal echocardiographic measurements of valvular motion, cavity dimensions, great vessel diameters, and right, left and septal wall thicknesses of children ranging in size from infants to full growth. The study group was composed of 205 normal, healthy children for whom echocardiograms and subsequent measurements were performed in a standardized manner. The following measurements were performed: left ventricular end-diastolic and end-systolic dimension, right ventricular end-diastolic cavity dimension, right ventricular end-diastolic anterior wall thickness, left ventricular end-diastolic posterior wall thickness, ventricular septal end-diastolic thickness, maximal left atrail dimension, end-diastolic aortic and pulmonary artery diameter, end-diastolic cardiac and septal depth, maximal aortic leaflet separation, and maximal anterior mitral and anterior tricupsid amplitude. Data are grouped into the fifth, fiftieth, and ninety-fifty percentiles according to body surface area. These graphs allow measurements of a single patient to be compared to normal measurements of individuals with similar body surface area.
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