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Related Experiment Video

Updated: Jul 6, 2026

Retrograde Perfusion and Filling of Mouse Coronary Vasculature as Preparation for Micro Computed Tomography Imaging
10:16

Retrograde Perfusion and Filling of Mouse Coronary Vasculature as Preparation for Micro Computed Tomography Imaging

Published on: February 10, 2012

Cardiopulmonary bypass. Microembolization and platelet aggregation.

R T Solis, P S Kennedy, A C Beall

    Circulation
    |July 11, 1975
    PubMed
    Summary

    Membrane oxygenation significantly reduces microemboli and preserves platelet function during cardiac surgery compared to bubble oxygenation, improving patient outcomes.

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    Area of Science:

    • Cardiovascular Surgery
    • Biomedical Engineering
    • Hematology

    Background:

    • Cardiac operations often require cardiopulmonary bypass using oxygenators.
    • Both bubble and membrane oxygenators are used, with potential differences in their impact on blood components.

    Purpose of the Study:

    • To compare the effects of bubble versus membrane oxygenators on particulate microemboli and platelet aggregation during cardiac operations.

    Main Methods:

    • Blood samples from patients undergoing cardiac operations were analyzed using an electronic particle size analyzer.
    • Microemboli and in vitro platelet aggregation were measured before, during, and after cardiopulmonary bypass with both bubble and membrane oxygenators.

    Main Results:

    • Membrane oxygenators generated fewer microemboli than bubble oxygenators.

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    Last Updated: Jul 6, 2026

    Retrograde Perfusion and Filling of Mouse Coronary Vasculature as Preparation for Micro Computed Tomography Imaging
    10:16

    Retrograde Perfusion and Filling of Mouse Coronary Vasculature as Preparation for Micro Computed Tomography Imaging

    Published on: February 10, 2012

    Optimization of the Cuff Technique for Murine Heart Transplantation
    14:01

    Optimization of the Cuff Technique for Murine Heart Transplantation

    Published on: June 26, 2020

    Blood Circuit Reconstruction in an Abdominal Mouse Heart Transplantation Model
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    Blood Circuit Reconstruction in an Abdominal Mouse Heart Transplantation Model

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  • Both oxygenator types increased cardiotomy return microemboli, but membrane oxygenation resulted in less platelet aggregation post-bypass.
  • Platelet loss exceeded hemodilution effects with both oxygenator types.

    • Conclusions:

    • Membrane oxygenation offers advantages over bubble oxygenation by reducing particulate microembolization.
    • Membrane oxygenation better preserves platelet function during cardiac operations, suggesting improved safety and efficacy.