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Related Experiment Videos

Severe HELLP syndrome remote from term.

F Gardeil1, G Gaffney, J J Morrison

  • 1Department of Obstetrics & Gynaecology, University College Hospital Galway. bgardeil@esatclear.ie

Irish Medical Journal
|April 26, 2001
PubMed
Summary
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Severe preeclampsia and HELLP syndrome at 21 weeks gestation necessitated early delivery to save the mother's life. This case highlights that delivery is the only cure for HELLP syndrome, even before fetal viability.

Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Nephrology

Background:

  • Severe preeclampsia and HELLP (Hemolysis, Elevated Liver enzymes, and Low Platelets) syndrome are critical obstetric emergencies.
  • Early-onset HELLP syndrome, particularly before fetal viability, presents significant management challenges.

Observation:

  • A 27-year-old nulliparous woman presented with severe preeclampsia and HELLP syndrome at 21 weeks gestation.
  • The patient also exhibited renal failure, necessitating urgent intervention.
  • Pregnancy termination was elected to preserve maternal life.

Findings:

  • Vaginal delivery was achieved after labor induction with misoprostol, resulting in a stillborn male fetus.
  • Maternal condition improved post-delivery, but postpartum renal impairment persisted.

Related Experiment Videos

  • HELLP syndrome requires delivery for definitive treatment; other interventions are palliative.

    • Implications:

    • This case underscores that delivery is the sole curative treatment for HELLP syndrome, irrespective of gestational age or fetal viability.
    • Conservative management is contraindicated in cases of HELLP syndrome occurring before fetal viability.
    • Prompt diagnosis and management are crucial for maternal survival in severe early-onset preeclampsia with HELLP syndrome.