Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet GP Ib/IX/V complex: physiological role.

J Rivera1, M L Lozano, J Corral

  • 1Unit of Hematology and Clinical Oncology, Hospital General Universitario and Centro Regional de Hemodonación, Murcia, Spain.

Journal of Physiology and Biochemistry
|April 26, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Is severity related to the utilization of resources? An exploration of the Duke Severity of Illness Scale (DUSOI)].

Atencion primaria·1998
Same author

Transfusion-related acute lung injury associated with an NA1-specific antigranulocyte antibody.

Haematologica·1998
Same author

The two poles of the lymphocyte: specialized cell compartments for migration and recruitment.

Cell adhesion and communication·1998
Same author

Expression in human prostate of drug- and carcinogen-metabolizing enzymes: association with prostate cancer risk.

British journal of cancer·1998
Same author

Delayed-type hypersensitivity to subcutaneous enoxaparin.

Allergy·1998
Same author

Occupational asthma by Anisakis simplex.

The Journal of allergy and clinical immunology·1998
Same journal

Relationship between muscle FNDC5, FGF21 mRNA, miR-150 and bone loss after sciatic denervation.

Journal of physiology and biochemistry·2026
Same journal

The regulatory effects of extracellular vesicles derived from adipose stem cells on tumor biological activity.

Journal of physiology and biochemistry·2026
Same journal

METTL3 suppresses pyroptosis in obstructive sleep apnea-associated hypertension via YTHDF2-mediated SOX4 mRNA degradation.

Journal of physiology and biochemistry·2026
Same journal

Mitochondria-sarcoplasmic reticulum crosstalk as a modulator of skeletal muscle mass.

Journal of physiology and biochemistry·2026
Same journal

Gene arrangement within concatemeric constructs governs the functional divergence of human and rat ASIC3 concatemers.

Journal of physiology and biochemistry·2026
Same journal

The two faces of mitochondrial Ca<sup>2+</sup> dysregulation in skeletal muscle: overload and deficiency.

Journal of physiology and biochemistry·2026
See all related articles

Platelet glycoprotein (GP) Ib/IX/V complex is crucial for blood clot formation under high shear stress. Further research is needed to understand the roles of associated proteins in signal transduction.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Hematology

Background:

  • Platelets are vital for hemostasis and thrombosis, especially in arterial vessels where high shear rates promote platelet-endothelial interactions.
  • Platelet activation involves adhesion, thrombin generation, aggregation, and release of intracellular products, critical for vascular injury response.

Purpose of the Study:

  • To investigate the role of the glycoprotein (GP) Ib/IX/V complex in platelet adhesion and signal transduction.
  • To explore the involvement of associated proteins, actin-binding protein (ABP) 280, 14-3-3zeta, FcgammaRIIA, and FcR gamma-chain, in GP Ib/IX/V mediated signaling.

Main Methods:

  • The study focuses on the molecular interactions and signaling pathways involving the GP Ib/IX/V complex.
  • Investigated the binding of von Willebrand factor (vWF) and thrombin to the GP Ib/IX/V complex.

Related Experiment Videos

  • Examined the association of ABP 280, 14-3-3zeta, FcgammaRIIA, and FcR gamma-chain with the GP Ib/IX/V complex.

    • Main Results:

    • The GP Ib/IX/V complex mediates platelet adhesion and aggregation under high shear flow by binding to the subendothelial matrix.
    • Proteins ABP 280 and 14-3-3zeta are identified as potential signal transducers for the GP Ib/IX/V complex.
    • FcgammaRIIA and FcR gamma-chain associate with the GP Ib/IX/V complex, suggesting a role in GPIbalpha-mediated signal transduction.

    Conclusions:

    • The GP Ib/IX/V complex is a key receptor initiating platelet activation and aggregation in response to vascular injury under high shear conditions.
    • Associated proteins ABP 280, 14-3-3zeta, FcgammaRIIA, and FcR gamma-chain play significant, though not fully elucidated, roles in GP Ib/IX/V signal transduction pathways.