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Updated: Aug 12, 2026

Primary Culture of Human Vestibular Schwannomas
Published on: July 20, 2014
Vestibular schwannomas: clinical presentation, management and outcome
M S Awan1, H U Qureshi, A A Sheikh
1Sections of Neurosurgery and Otolaryngology, Department of Surgery, Aga Khan University, Karachi.
Objective:
To review the demographic trends clinical spectrum, diagnosis, management and out come of patients with vestibular Schwannoma and to identify areas where improvements are needed.
Methods:
All patients with vestibular schwannoma admitted to the Aga Khan University Hospital over the past 11 years were reviewed retrospectively.
Results:
The age range of majority of 22 patients analyzed, was 41-50 years (23%). Hearing loss was the most common presenting symptom (96%). Other clinical features included cranial nerve palsies (59%) and headache (55%). Fifty percent had signs of raised intracranial pressure. Neuroimaging revealed "Stage IV b" (tumor distorting the brainstem and compressing the 4th ventricle) in 50% cases. Neurosurgical intervention was carried out in 86%; mainly using the retrosigmoid approach. Postoperative complications included facial nerve palsy in 13 (65%) and hydrocephalus in 5 (25%) patients. Hearing determined clinically was preserved in three patients (14%). One patient died during the inpatient stay.
Conclusion:
Presentation of these patients is late and the outcome is poor.
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