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[Malformations in cortical development in patients with epilepsy. Neuroimaging of 17 cases]

S Carvalho1, O Brito, E Machado

  • 1Serviços de Nerorradiologia e Neurologia, Hospitais da Universidade de Coimbra, Coimbra.

Acta Medica Portuguesa
|April 27, 2001
PubMed

Insights

Malformations of Cortical Development (MCD) occurred in 7.1% of epilepsy patients, diagnosed via MRI. Polymicrogyria and heterotopia were most common, often affecting frontal lobes, highlighting MCD's spectrum in epilepsy.

Area of Science:

  • Neurology
  • Neuroimaging
  • Developmental Neuroscience

Context:

  • Epilepsy is a chronic neurological disorder characterized by recurrent seizures.
  • Malformations of Cortical Development (MCD) are a significant cause of epilepsy, particularly in pediatric and adult populations.
  • Magnetic Resonance Imaging (MRI) is a key diagnostic tool for identifying MCD.

Purpose:

  • To review the frequency and types of Malformations of Cortical Development (MCD) diagnosed by Magnetic Resonance Imaging (MRI) in patients with epilepsy.
  • To identify the most common MCD subtypes and frequently affected brain regions in this cohort.
  • To underscore the diverse spectrum of MCD contributing to epilepsy.

Summary:

  • A five-year review of epilepsy patients diagnosed with MCD via MRI revealed a 7.1% frequency.
  • The most prevalent MCD subtypes were polymicrogyria (35.3%), heterotopia (29.4%), and focal cortical dysplasia (29.4%).
  • Focal or multifocal MCDs were common, with the frontal lobes being the most frequently affected brain regions.

Impact:

  • This study highlights the significant prevalence of MCD in epilepsy patients.
  • Understanding the spectrum of MCD in epilepsy aids in diagnosis and potential therapeutic strategies.
  • The findings emphasize the importance of advanced neuroimaging like MRI in diagnosing MCD-related epilepsy.

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