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The HELLP syndrome: maternal and perinatal outcome
D Murray1, M O'Riordan, M Geary
1Department of Paediatrics, Rotunda Hospital, Dublin.
Irish Medical Journal
|April 27, 2001
Summary
HELLP syndrome, a rare obstetric emergency, presents significant risks to mothers and infants. This study found high maternal and neonatal morbidity but no maternal deaths, with outcomes linked to gestational age at delivery.
Area of Science:
- Obstetrics
- Maternal-Fetal Medicine
- Neonatology
Background:
- HELLP syndrome (Hemolysis, Elevated Liver enzymes, and Low Platelets) is a severe condition complicating pregnancy.
- It is associated with significant maternal and perinatal mortality and morbidity.
- Understanding outcomes is crucial for clinical management.
Purpose of the Study:
- To evaluate maternal and perinatal outcomes in HELLP syndrome cases.
- To identify key complications and risk factors.
- To inform clinical practice and improve patient care.
Main Methods:
- Retrospective review of 20 HELLP syndrome cases from January 1995 to September 1999.
- Data collected included antenatal, intrapartum, and neonatal information.
- Maternal and neonatal complications were specifically recorded.
Main Results:
- Maternal morbidity was high (95% admitted to High Dependency Unit) but resolved; no maternal deaths occurred.
- Neonatal morbidity was significant, with 70% NICU admissions and 40% developing RDS.
- Perinatal deaths (2) occurred in infants <500g; outcomes strongly correlated with preterm delivery.
Conclusions:
- While maternal morbidity is high, it is generally short-term with full recovery.
- Neonatal morbidity is substantial and directly related to the degree of prematurity.
- Prompt delivery upon diagnosis is critical for managing HELLP syndrome.