Related Experiment Videos
Familial inheritance of crossed fused renal ectopia
C Rinat1, A Farkas, Y Frishberg
1Division of Pediatric Nephrology, Shaare Zedek Medical Center, Hebrew University-Hadassah School of Medicine, Jerusalem, Israel.
Pediatric Nephrology (Berlin, Germany)
|April 27, 2001
Abstract:
A family with dominant inheritance of a rare renal malformation is reported. The father and one son had left crossed fused ectopic and dysplastic kidneys and another son had a horseshoe kidney and vesicoureteral reflux. We discuss various potential pathogenetic mechanisms and propose that a defect in the timing of the proper reciprocal induction of the ureteric bud and the metanephric blastema is involved.