Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Proteomic profiling from human samples: the body fluid alternative.

S Kennedy1

  • 1Oxford GlycoSciences Ltd, The Forum, 86 Milton Park, Oxon OX14 4RY, Abingdon, UK. sandy.kennedy@ogs.co.uk

Toxicology Letters
|April 27, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vitreoretinal large B- cell lymphoma (VR- LBCL): Clinical and pathological features and treatment outcomes.

Pathology, research and practice·2024
Same author

Plasma-activated liquid as a potential decontaminant in healthcare: assessment of antibacterial activity and use with cleaning cloths.

The Journal of hospital infection·2024
Same author

Four Models of Wastewater-Based Surveillance for SARS-CoV-2 in Jail Settings: How Monitoring Wastewater Complements Individual Screening.

medRxiv : the preprint server for health sciences·2023
Same author

The application of human reliability analysis to carpal tunnel decompression.

Annals of the Royal College of Surgeons of England·2023
Same author

Comparison of multistate model, survival regression, and matched case-control methods for estimating excess length of stay due to healthcare-associated infections.

The Journal of hospital infection·2022
Same author

Epidemiology of healthcare-associated infection reported from a hospital-wide incidence study: considerations for infection prevention and control planning.

The Journal of hospital infection·2021
Same journal

hERG Channel Blockade and Additive Interactions of Magnolol and Honokiol from Magnolia Species.

Toxicology letters·2026
Same journal

Evaluation of dose-dependent hematotoxic effects of celastrol on human blood cells in vitro.

Toxicology letters·2026
Same journal

Environmental pharmaceutical and antibiotic mixtures: An exposomics-guided framework for mechanistic toxicology.

Toxicology letters·2026
Same journal

Size- and morphology-dependent cytotoxicity of metal-organic frameworks: Deciphering the structure-toxicity relationship.

Toxicology letters·2026
Same journal

Steroidogenesis suppression in H295R cells by 1,3-disubstituted ureas: A potential off-target effect of some sEH inhibitors.

Toxicology letters·2026
Same journal

Signaling pathways in tobacco smoking-induced cervical carcinogenesis: Beyond HPV-mediated activation.

Toxicology letters·2026
See all related articles

Proteomics enables detailed protein analysis from body fluids, offering insights into disease and drug development. This technology complements genomics by revealing protein changes missed at the gene expression level.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Drug Development

Background:

  • Proteomics is a rapidly advancing field crucial for modern drug development.
  • It involves systematic separation, identification, and characterization of proteins in biological samples.
  • Proteomics complements genomics, as gene activity doesn't always correlate with protein abundance, especially when drug actions interfere with protein synthesis.

Purpose of the Study:

  • To describe the applications of proteomics, with a focus on analyzing body fluid samples.
  • To highlight how proteomics can identify organ toxicity by comparing protein expression in diseased versus normal samples.
  • To demonstrate the utility of proteomics in uncovering disease markers and treatment responses.

Main Methods:

  • Proteomic analysis of biological samples, including body fluids like serum, urine, and cerebrospinal fluid.

Related Experiment Videos

  • High-throughput, automated techniques for protein analysis.
  • Comparative analysis of protein profiles between healthy and diseased states.

    • Main Results:

    • Proteomics provides a more complete picture of pathological processes than genomics alone.
    • Analysis of body fluids via proteomics offers insights derived from multiple tissues and processes.
    • Identified surrogate markers for conditions such as hepatocellular carcinoma and breast cancer, and for gentamicin toxicity.

    Conclusions:

    • Proteomics is a powerful tool for drug development and understanding disease mechanisms.
    • Analysis of body fluids using proteomics is uniquely valuable due to its comprehensive nature.
    • Proteomics facilitates the identification of novel biomarkers for early disease detection and therapeutic monitoring.