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A simple and inexpensive preparation of [(51)Cr]-MAA particles
C Tsopelas1, S Brundell, B E Chatterton
1RAH Radiopharmacy, Royal Adelaide Hospital, North Terrace, 5000, Adelaide, Australia. ctsopela@mail.rah.se.gov.au
Abstract:
The feasibility of preparing [(51)Cr]-MAA was investigated using an MAA cold kit and commercially available sodium [(51)Cr]chromate solutions. Of different conditions tested, the best required an addition of a low level of sodium dithionite to achieve a radiolabeling efficiency of 44%. The product was purified by centrifugation to give [(51)Cr]-MAA with 99 +/- 1% radiochemical purity (RCP) comprised of >94% radioactive particles >10 microm, and resulted in a rat biodistribution with >80% in the lungs. [(51)Cr]-MAA is inexpensive, easily and conveniently prepared by this procedure.
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