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A role for eosinophils in transplant rejection
M Goldman1, A Le Moine, M Braun
1Laboratory of Experimental Immunology, Faculty of Medicine, Université Libre de Bruxelles, 808 route de Lennik, B-1070 Brussels, Belgium. mgoldman@ulb.ac.be
Trends in Immunology
|April 27, 2001
Summary
Eosinophils contribute to allergic diseases and transplant rejection. Their role in transplant damage is significant when T helper 2 cells dominate the immune response after conventional rejection pathways are blocked.
Area of Science:
- Immunology
- Allergic Diseases
- Transplantation
Background:
- Eosinophils release inflammatory mediators and cationic proteins.
- These mediators are key in allergic diseases like bronchial asthma.
- Experimental data suggest eosinophils also play a role in allograft rejection.
Purpose of the Study:
- To review experimental evidence on eosinophils' role in allograft rejection.
- To propose a mechanism for eosinophil involvement in transplant rejection.
- To highlight the importance of eosinophils in specific immune contexts.
Main Methods:
- Review of experimental observations.
- Analysis of immune response pathways in transplantation.
- Focus on T helper 2 cell-dominated responses.
Main Results:
- Eosinophils are implicated in the pathogenesis of allergic diseases.
- Evidence indicates eosinophils contribute to allograft rejection.
- Eosinophil effector functions become critical in specific immune environments.
Conclusions:
- Eosinophils are involved in both allergic inflammation and transplant rejection.
- Their role in transplant damage is particularly crucial when T helper 2 cells are dominant and classical rejection pathways are inhibited.