Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gene-environment interactions in renal cell carcinoma.

J C Semenza1, A Ziogas, J Largent

  • 1School of Community Health, College of Urban and Public Affairs, Portland State University, Portland, OR 97207-0751, USA. semenzaj@pdx.edu

American Journal of Epidemiology
|April 27, 2001
PubMed
Summary

Individuals with slow N-acetyltransferase 2 (NAT2) genotypes have a higher risk of developing renal cell carcinoma (RCC), especially when exposed to smoking. This gene-environment interaction highlights personalized risk factors for kidney cancer.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The attribution of human health outcomes to climate change: a transdisciplinary guidance document.

Climatic change·2025
Same author

Association of gene variant type and location with breast cancer risk in the general population.

Annals of oncology : official journal of the European Society for Medical Oncology·2025
Same author

Authors' Response to Correspondence Re Ethnic Differences in Radiotherapy Outcomes in a Majority South Asian Leicester Community.

Clinical oncology (Royal College of Radiologists (Great Britain))·2024
Same author

Oral Cavity Cancers: Ethnic Differences in Radiotherapy Outcomes in a Majority South Asian Leicester Community.

Clinical oncology (Royal College of Radiologists (Great Britain))·2024
Same author

Outcomes from a Cancer Centre of Intensity-modulated Radiotherapy in Patients with Squamous Cell Carcinoma of the Head and Neck.

Clinical oncology (Royal College of Radiologists (Great Britain))·2021
Same author

Association of IRF4 single-nucleotide polymorphism rs12203592 with melanoma-specific survival.

The British journal of dermatology·2020

Area of Science:

  • Oncology
  • Genetics
  • Environmental Health

Background:

  • Renal cell carcinoma (RCC) incidence is rising, with smoking identified as a significant environmental risk factor.
  • N-acetyltransferase 2 (NAT2) is an enzyme involved in metabolizing tobacco carcinogens, exhibiting genetic polymorphism.
  • Understanding gene-environment interactions is crucial for elucidating RCC etiology.

Purpose of the Study:

  • To investigate the association between NAT2 genotypes and RCC risk.
  • To explore the interaction between NAT2 genotype and smoking in RCC development.
  • To identify specific genetic predispositions that modify smoking-related kidney cancer risk.

Main Methods:

  • A case-control study was conducted using RCC cases and population-based controls from Orange County, California (1994-1997).

Related Experiment Videos

  • Genotyping for N-acetyltransferase 2 (NAT2) was performed on 115 cases and 259 controls.
  • Statistical analysis included odds ratios (OR) and confidence intervals (CI) with stratified analyses for gene-environment interactions.

    • Main Results:

    • Individuals with slow NAT2 acetylator genotypes exhibited a twofold increased risk of RCC (OR = 1.8; 95% CI: 1.1, 2.9).
    • Smoking independently increased RCC risk (OR = 2.2; 95% CI: 1.3, 3.7).
    • A significant gene-environment interaction was observed: slow acetylators who smoked had a substantially higher RCC risk (OR = 3.2; 95% CI: 1.7, 6.1) compared to rapid acetylators who smoked (OR = 1.4; 95% CI: 0.7, 2.9).
    • A dose-response relationship between smoking pack-years and RCC risk was evident in slow acetylators (p < 0.01).

    Conclusions:

    • The study suggests that NAT2 genotype significantly modifies smoking-related RCC risk.
    • Slow NAT2 acetylator status amplifies the risk of kidney cancer among smokers.
    • These findings underscore the importance of genetic factors in personalized RCC risk assessment, particularly concerning environmental exposures like smoking.