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Related Experiment Videos

Increased brain apparent diffusion coefficient in children with neurofibromatosis type 1.

J D Eastwood1, D J Fiorella, J F MacFall

  • 1Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710, USA. eastw004@mc.duke.edu

Radiology
|April 27, 2001
PubMed
Summary

Children with neurofibromatosis type 1 (NF 1) show increased brain water diffusibility in multiple brain areas and in hyperintense lesions. These findings highlight altered brain microstructure in NF 1.

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Area of Science:

  • Neuroimaging
  • Pediatric Neurology
  • Diffusion Tensor Imaging

Background:

  • Neurofibromatosis type 1 (NF 1) is a genetic disorder that can affect brain development.
  • Altered brain water diffusibility may indicate underlying microstructural changes in NF 1.

Purpose of the Study:

  • To compare brain water diffusibility in children with NF 1 versus controls.
  • To examine diffusibility changes in specific brain regions and associated with basal ganglia lesions in NF 1.

Main Methods:

  • Studied 20 pairs of children with NF 1 and matched controls.
  • Measured apparent diffusion coefficient (ADC) values in five brain locations.
  • Analyzed T2-hyperintense globus pallidus lesions retrospectively.

Main Results:

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  • NF 1 group showed significantly increased ADC values in all five locations.
  • Greatest increases observed in globus pallidus and brachium pontis.
  • Increased ADC values were present in hyperintense lesions and normal-appearing NF 1 brain areas.

Conclusions:

  • Children with NF 1 exhibit widespread increases in brain water diffusibility.
  • Both hyperintense lesions and normal-appearing brain tissue show altered diffusion in NF 1.
  • These findings suggest microstructural abnormalities in the NF 1 brain.