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Rapid aortic wave velocity measurement with MR imaging
V V Itskovich1, K A Kraft, D Y Fei
1Department of Biomedical Engineering, Medical College of Virginia of Virginia Commonwealth University, 1101 E Marshall St, Rm B3-020, Richmond, VA 23298-0072, USA.
Radiology
|April 27, 2001
Summary
This study shows that one-dimensional magnetic resonance (MR) imaging can accurately measure aortic wave velocity in people. Higher wave velocity was linked to older age, suggesting MR is a valuable tool for cardiovascular assessment.
Area of Science:
- Cardiovascular Imaging
- Biomedical Engineering
- Medical Physics
Background:
- Aortic wave velocity is a key indicator of cardiovascular health.
- Accurate in vivo measurement of aortic wave velocity is crucial for clinical assessment.
- Existing methods for measuring wave velocity may have limitations in speed or accuracy.
Purpose of the Study:
- To evaluate the utility of a one-dimensional magnetic resonance (MR) sequence for rapid and accurate in vivo measurement of aortic wave velocity.
- To validate the MR method using a compliant tube model.
- To investigate the correlation between aortic wave velocity, blood velocity, and subject age.
Main Methods:
- A one-dimensional MR sequence was developed and applied.
- Studies were conducted on the thoracic aortas of 20 healthy human subjects.
- The MR method was validated using a compliant tube model simulating aortic conditions.
Main Results:
- Aortic wave velocity in healthy subjects ranged from 3.8 to 9.7 m/sec.
- A significant positive correlation was observed between aortic wave velocity and subject age.
- Peak blood velocity ranged from 47 to 125 cm/sec, showing a strong negative correlation with age.
Conclusions:
- One-dimensional MR imaging provides a rapid and accurate method for measuring in vivo aortic wave velocity.
- Age-related changes in aortic wave velocity and peak blood velocity were successfully quantified.
- This MR technique holds promise for non-invasive cardiovascular assessment and monitoring of age-related vascular changes.