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Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
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IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity.

V Shankaran1, H Ikeda, A T Bruce

  • 1Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA.

Nature
|April 27, 2001
PubMed
Summary

The immune system, including lymphocytes and interferon-gamma (IFNγ), acts as a tumor suppressor by preventing cancer development. However, this process also selects for cancer cells that can evade immune detection.

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