Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The extracellular matrix in multiple sclerosis: an update.

R A Sobel1

  • 1Pathology and Laboratory Services, Veterans Affairs Health Care System, Palo Alto and Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. raysobel@stanford.edu

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
|April 27, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acamprosate modulates experimental autoimmune encephalomyelitis.

Inflammopharmacology·2011
Same author

Temporal expression of inflammatory mediators in brain basilar artery vasculitis and cerebrospinal fluid of rabbits with coccidioidal meningitis.

Clinical and experimental immunology·2006
Same author

White matter extracellular matrix chondroitin sulfate/dermatan sulfate proteoglycans in multiple sclerosis.

Journal of neuropathology and experimental neurology·2002
Same author

The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease.

Science (New York, N.Y.)·2001
Same author

Mild hypothermia increases Bcl-2 protein expression following global cerebral ischemia.

Brain research. Molecular brain research·2001
Same author

Reversal of early diffusion-weighted magnetic resonance imaging abnormalities does not necessarily reflect tissue salvage in experimental cerebral ischemia.

Stroke·2001
Same journal

RETRACTION: NOP14 inhibits melanoma proliferation and metastasis by regulating Wnt/β-catenin signaling pathway.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
Same journal

RETRACTION: Differential expression of microRNA-411 and 376c is associated with hypertension in pregnancy.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
Same journal

RETRACTION: Comparison of two treatments for dry eye disease after corneal refractive surgery.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
Same journal

The emerging role of the microbiome in bladder cancer: prognostic implications and treatment response.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
Same journal

Standardizing the lateral fluid percussion model of trauma in marmosets (Callithrix jacchus): regional vulnerability and inflammatory response.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
Same journal

COVID-19 mortality risk among women with ovarian cancer: a matched case-control study.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
See all related articles

Extracellular matrix molecules in multiple sclerosis (MS) lesions impact axon regeneration. Enhanced proteoglycans in active MS lesions inhibit axon growth, contributing to CNS damage.

Area of Science:

  • Neuroscience
  • Immunology
  • Pathobiology

Background:

  • Extracellular matrix (ECM) molecules are crucial in the central nervous system (CNS) inflammatory disease multiple sclerosis (MS).
  • Recent research highlights CNS endothelial cell interactions with vascular basement membrane ECM during immune responses.
  • White matter ECM molecules influence demyelination and remyelination in MS lesions.

Purpose of the Study:

  • To review recent findings on ECM molecule roles in MS.
  • To investigate the impact of ECM remodeling on axon regeneration in MS.
  • To analyze ECM alterations in MS lesions using immunohistochemical studies.

Main Methods:

  • Mini-review of recent scientific literature.
  • Immunohistochemical analysis of MS lesions.

Related Experiment Videos

  • Characterization of ECM proteoglycans, including versican and dermatan sulfate proteoglycans.

    • Main Results:

    • Enhanced deposition of versican and dermatan sulfate proteoglycans observed at the edges of inflammatory MS lesions.
    • These proteoglycans inhibit neurite and axon growth, suggesting early involvement in active lesion expansion.
    • Decreased ECM proteoglycans and myelin in plaque centers indicate ECM injury.

    Conclusions:

    • White matter ECM proteoglycan alterations are integral to MS pathology across all disease stages.
    • ECM changes contribute to a CNS environment that hinders axon regrowth and regeneration.
    • Targeting ECM remodeling may offer therapeutic strategies for promoting CNS repair in MS.