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Updated: Sep 1, 2026

Coordinate Mapping of Hyolaryngeal Mechanics in Swallowing
Published on: May 6, 2014
Relationship between severity of reflux esophagitis according to the Los Angeles classification and esophageal
T Sugiura1, K Iwakiri, M Kotoyori
1Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
Purpose:
We investigated the relationship between the severity of reflux esophagitis (RE) according to the Los Angeles (LA) classification and esophageal motility.
Methods:
We examined 28 healthy subjects (HS) and 48 RE patients (grade A of the LA classification, 16 patients; grade B, 16 patients; grade C or D, 16 patients). Esophageal manometry was performed by the intraluminal microtransducer method. Resting lower esophageal sphincter (LES) pressure was assessed by the rapid pull-through method. Esophageal contraction after ten repeated 5-ml water swallowings separated by 30-s intervals was measured at 3, 8, 13, and 18 cm above the LES.
Results:
The resting LES pressure and the amplitude of esophageal contraction 3 cm above the LES in the grades C + D group were significantly lower than those in the HS group. The amplitude of esophageal contraction 3 cm above the LES in the grade B group was significantly lower than those in the grade A group and the HS group. The frequency of failed peristalsis in the grades C + D group was significantly higher than that in the HS group and the grade A and grade B groups.
Conclusions:
The present findings suggested that the severity of RE according to the LA classification would be likely to mainly reflect esophageal volume clearance.
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