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Serum lipoprotein(a) and its relation to left ventricular thrombus in patients with acute myocardial infarction

S Celik1, M Baykan, C Orem

  • 1KTU Faculty of Medicine, Department of Cardiology, Trabzon, Turkey.

Japanese Heart Journal
|April 28, 2001
PubMed

Insights

Lipoprotein(a) does not appear to be a risk factor for left ventricular (LV) thrombus formation in patients with acute myocardial infarction (AMI). Peak creatine kinase levels and LV wall motion score index are the best predictors of LV thrombus after AMI.

Area of Science:

  • Cardiology
  • Biochemistry
  • Thrombosis

Background:

  • Left ventricular (LV) thrombosis is common in acute myocardial infarction (AMI).
  • Lipoprotein(a) (Lp(a)), due to its structural similarity to plasminogen, may influence fibrinolysis and thrombosis.
  • The specific role of Lp(a) levels in LV thrombus formation post-AMI remains understudied.

Purpose of the Study:

  • To investigate whether Lp(a) levels are a risk factor for LV thrombus development in patients experiencing their first anterior AMI.
  • To identify independent predictors of LV thrombus formation in this patient cohort.

Main Methods:

  • Analysis of clinical, echocardiographic, and biochemical data from 102 patients with first anterior AMI.
  • Echocardiography performed serially on days 1, 3, 7, 15, and 30 post-AMI.
  • Plasma Lp(a) and fibrinogen levels measured via enzyme-linked immunosorbent assay and immunonephelometry, respectively, within 12 hours of symptom onset.

Main Results:

  • LV thrombus was detected in 20.3% of patients.
  • No significant difference in admission Lp(a) levels was observed between patients with and without LV thrombus (30.5±17.2 vs 32.3±22.4 mg/dl, p=0.7).
  • Independent predictors for LV thrombus formation identified through multivariate analysis were higher peak creatine kinase levels (p=0.04) and higher LV wall motion score index (p=0.002).

Conclusions:

  • Lp(a) is not identified as a risk factor for LV thrombus formation in patients with AMI.
  • Elevated peak creatine kinase levels and impaired LV wall motion are significant predictors of LV thrombus development following AMI.

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