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Updated: Aug 15, 2026
Rapid Determination of the Thermal Nociceptive Threshold in Diabetic Rats
Published on: May 17, 2012
Antinociceptive effect of vitamin K2 (menatetrenone) in diabetic mice
K Onodera1, K Zushida, J Kamei
1Department of Dental Pharmacology, Okayama University Dental School, Japan. onoderak@md.okayama-u.ac.jp
Abstract:
The antinociceptive effect of vitamin K2 (menatetrenone) in diabetic mice was examined using a tail-pressure test. Intraperitoneal injection of menatetrenone (10-100 mg/kg) produced a dose-dependent increase in the nociceptive threshold in diabetic mice. There was no significant difference between non-diabetic and diabetic mice in the menatetrenone-induced changes in the nociceptive threshold. The results suggest the therapeutical usefulness of menatetrenone for treating painful diabetic neuropathy and osteoporosis.
