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Calcium signaling and annexins
T E Hawkins1, C J Merrifield, S E Moss
1Laboratory for Molecular Cell Biology, University College London, UK.
Cell Biochemistry and Biophysics
|April 28, 2001
Summary
Annexins are calcium-binding proteins with emerging roles as ion channels and regulators. This review explores their potential in intracellular calcium signaling and ion flux control.
Area of Science:
- Biochemistry
- Molecular Biology
- Cell Physiology
Background:
- Annexins are a family of calcium ion (Ca2+)-binding proteins with largely unknown physiological functions.
- Proposed roles include vesicle trafficking, but this review focuses on their potential as ion channels or regulators.
Purpose of the Study:
- To review the evidence for annexins acting as atypical ion channels or modulators of ion channel activity.
- To explore the proposed roles of annexins in intracellular calcium (Ca2+) signaling and homeostasis.
Main Methods:
- Review of in vitro and structural analyses of annexin proteins.
- Examination of evidence for annexin roles in intracellular Ca2+ signaling.
- Analysis of structural and electrophysiological data.
Main Results:
- Increasing evidence suggests some annexins function in intracellular Ca2+ signaling.
- Annexins may act as atypical ion channels and/or modulators of ion channel activity.
- Structural and electrophysiological data support roles in controlling ion fluxes.
Conclusions:
- Annexins show potential as key players in intracellular calcium homeostasis.
- Further research is needed to fully elucidate the physiological roles of annexins in ion transport.