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A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction
Published on: December 20, 2014
Laparoscopic ureteral reconstruction with small intestinal submucosa
E N Liatsikos1, C Z Dinlenc, R Kapoor
1Department of Urology, Albert Einstein College of Medicine, Long Island Jewish Medical Center, New Hyde Park, New York 11040, USA.
Journal of Endourology
|April 28, 2001
Summary
Laparoscopic ureteral reconstruction using small intestinal submucosa (SIS) is feasible in pigs. This technique effectively regenerates ureteral tissue, showing promising results for future clinical applications.
Area of Science:
- Urology
- Regenerative Medicine
- Minimally Invasive Surgery
Background:
- Ureteral reconstruction presents surgical challenges.
- Small intestinal submucosa (SIS) is a promising biomaterial for tissue engineering.
Purpose of the Study:
- To assess the feasibility of laparoscopic ureteral reconstruction using SIS in a porcine model.
Main Methods:
- Laparoscopic ureteral defect creation and repair with SIS in eight pigs.
- Standardized surgical approach with 10-mm ports.
- Assessment via retrograde pyelography and histological analysis after 7 weeks.
Main Results:
- Successful laparoscopic reconstruction in all animals.
- No obstructive phenomena observed post-procedure.
- Histology confirmed SIS scaffolds integrated and regenerated ureteral tissue effectively.
Conclusions:
- Laparoscopic ureteral reconstruction with SIS is technically feasible and effective.
- SIS acts as a biodegradable scaffold promoting host tissue regeneration.
- This approach holds potential for clinical ureteral repair.
