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Anti-HIV prenylated flavonoids from Monotes africanus
K M Meragelman1, T C McKee, M R Boyd
1Laboratory of Drug Discovery Research and Development, Division of Basic Sciences, National Cancer Institute, NCI-Frederick, Frederick, Maryland 21702-1201, USA.
Journal of Natural Products
|April 28, 2001
Abstract:
Six flavonoids, among them a new dihydroflavonol, 6,8-diprenylaromadendrin (1), and the flavonol 6,8-diprenylkaempferol (3), have been isolated from the organic extract of Monotes africanus. The isolated compounds containing a 5,7-dihydroxy-6,8-diprenyl system in the A ring of the flavonoid (1, 3, and 6) exhibited HIV-inhibitory activity in the XTT-based, whole-cell screen. In addition, several (13)C NMR assignments of lonchocarpol A (6) were corrected.