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Lipopolysaccharide induces memory-processing deficits in day-old chicks.

K M Sell1, S F Crowe, S Kent

  • 1School of Psychological Science, La Trobe University, Victoria 3083, Bundoora, Australia.

Pharmacology, Biochemistry, and Behavior
|April 28, 2001
PubMed
Summary

Immune activation, triggered by lipopolysaccharide (LPS), impairs memory in young chicks. This study shows LPS administration before training disrupts memory processing, particularly during the shift from short-term to intermediate-term memory.

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Area of Science:

  • Neuroimmunology
  • Cognitive Neuroscience
  • Animal Models

Background:

  • Immune system activation is linked to cognitive impairments.
  • Proinflammatory cytokines play a role in these deficits.
  • Lipopolysaccharide (LPS) is a common tool to induce immune responses.

Purpose of the Study:

  • To investigate the impact of peripheral lipopolysaccharide (LPS) administration on memory processes.
  • To determine the dose- and time-dependency of LPS effects on memory.
  • To identify the specific memory stages affected by LPS.

Main Methods:

  • Day-old chicks were trained on a single-trial passive-avoidance task.
  • Peripheral administration of varying doses of LPS was performed before training.
  • Retention tests were conducted at different time points post-training.

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Main Results:

  • LPS impaired passive-avoidance performance in a dose- and time-dependent manner.
  • Maximal memory impairment occurred with a 2.5-mg/kg LPS dose given 60 minutes before training.
  • Memory processing deficits were observed between 10 and 20 minutes post-training.

Conclusions:

  • Peripheral LPS administration inhibits memory processing in young chicks.
  • The inhibitory effect is most pronounced at the transition from short-term to intermediate-term memory.
  • This highlights the role of immune activation in modulating cognitive function.