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Clinical thermometry, using the 27 MHz multi-electrode current-source interstitial hyperthermia system in brain
R S Kaatee1, P C Nowak, J van der Zee
1Division of Clinical Physics, Department of Radiotherapy, Daniel den Hoed Cancer Center, University Hospital Rotterdam, Groene Hilledijk 301, 3075 EA, The, Rotterdam, Netherlands.
Summary
Estimating brain lesion temperatures during interstitial hyperthermia is challenging. This study shows that using temperature decay methods with the multi-electrode current-source interstitial hyperthermia (MECS-IHT) system allows for adequate brain heating.
Area of Science:
- Oncology
- Medical Physics
- Neurosurgery
Background:
- Interstitial hyperthermia temperature measurements often reflect maximum applicator temperatures, not heterogeneous tissue distributions.
- Accurate temperature monitoring is crucial for effective thermal ablation in brain tumors.
Purpose of the Study:
- To investigate methods for estimating lesion temperatures within the brain using a multi-electrode current-source interstitial hyperthermia (MECS-IHT) system.
- To determine the feasibility of adequate brain heating with the MECS-IHT system.
Main Methods:
- Temperature measurements were taken within electrodes and in an external catheter near a glioblastoma resection cavity.
- Local maximum and minimum tissue temperatures were inferred from temperature decay data during power-off periods.
- Model calculations were used to validate the significance of the temperature decay data.
Main Results:
- Maximum tissue temperatures could be estimated by briefly switching off electrodes.
- Minimum tissue temperatures near an afterloading catheter correlated well with applicator temperatures post-shutdown.
- Model calculations confirmed the utility of temperature decay for assessing thermal distribution.
Conclusions:
- Direct electrode temperature readings during heating are insufficient for assessing temperature distribution.
- The MECS-IHT system can achieve adequate brain heating when supplemented with external sensors or temperature decay analysis.
- Temperature decay methods offer a feasible approach for monitoring and controlling interstitial hyperthermia in the brain.