Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Crystalline solids.

S R Vippagunta1, H G Brittain, D J Grant

  • 1Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Weaver-Densford Hall, 308 Harvard Street S.E., Minneapolis, MN 55455, USA.

Advanced Drug Delivery Reviews
|April 28, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predicting outcome in ex-premature infants supported with extracorporeal membrane oxygenation for acute hypoxic respiratory failure.

Archives of disease in childhood. Fetal and neonatal edition·2004
Same author

Molecular modeling study of chiral drug crystals: lattice energy calculations.

Journal of pharmaceutical sciences·2001
Same author

Polymorph screening: influence of solvents on the rate of solvent-mediated polymorphic transformation.

Journal of pharmaceutical sciences·2001
Same author

Hydrogen bonding in sulfonamides.

Journal of pharmaceutical sciences·2001
Same author

Estimating the relative stability of polymorphs and hydrates from heats of solution and solubility data.

Journal of pharmaceutical sciences·2001
Same author

Influence of crystal structure on the tableting properties of sulfamerazine polymorphs.

Pharmaceutical research·2001

Understanding drug solid-state forms like polymorphs is crucial for stability and handling. Advances in computational tools and analytical methods aid in predicting and characterizing these crystalline structures.

Area of Science:

  • Pharmaceutical Science
  • Solid-State Chemistry
  • Materials Science

Background:

  • Drugs are often formulated as crystalline solids for stability and handling.
  • Crystalline solids can exist as polymorphs, solvates, or hydrates, influencing drug properties.
  • Phase transitions in solid-state forms can alter drug dissolution and transport.

Purpose of the Study:

  • To review recent advancements in predicting and characterizing drug polymorphs and solvates.
  • To highlight challenges faced by pharmaceutical scientists in solid-state drug development.
  • To anticipate future research directions in solid-state pharmaceutical science.

Main Methods:

  • Utilizing computational tools for predicting potential drug polymorphs from molecular structures.

Related Experiment Videos

  • Developing sensitive analytical methods for characterizing crystalline forms in dosage forms.
  • Reviewing literature on solid-state phase transitions and their impact on drug behavior.

    • Main Results:

    • Computational methods offer insights into the origins of polymorphism at the molecular level.
    • Advanced analytical techniques enable detailed characterization of various crystalline forms.
    • Understanding and controlling solid-state forms are key for optimal drug development.

    Conclusions:

    • Choosing the most stable drug form early in development is essential.
    • Continued research in prediction and characterization is vital for pharmaceutical innovation.
    • Future developments will likely focus on integrated computational and experimental approaches.