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Related Experiment Videos

Characterization of the solid-state: spectroscopic techniques.

D E Bugay1

  • 1SSCI Inc., 3065 Kent Avenue, West Lafayette, IN 47906, USA. debugay@ssci-inc.com

Advanced Drug Delivery Reviews
|April 28, 2001
PubMed
Summary
This summary is machine-generated.

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Solid-state spectroscopy techniques are crucial for characterizing pharmaceutical solids, including active ingredients and final dosage forms. This review covers infrared, Raman, and solid-state NMR for qualitative and quantitative analysis.

Area of Science:

  • Pharmaceutical Science
  • Analytical Chemistry
  • Materials Science

Background:

  • Physical characterization of pharmaceutical solids is essential for drug development.
  • Solid-state spectroscopy offers powerful tools for analyzing drug substances and formulations.
  • Understanding solid-state properties impacts drug efficacy and stability.

Purpose of the Study:

  • To review the application of solid-state spectroscopy in pharmaceutical physical characterization.
  • To provide an overview of infrared (IR), Raman, and solid-state Nuclear Magnetic Resonance (NMR) techniques.
  • To introduce solid-state imaging methods like IR, Raman, and Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS).

Main Methods:

  • Review of experimental techniques for solid-state spectroscopy (IR, Raman, NMR).

Related Experiment Videos

  • Discussion of qualitative and quantitative analytical applications.
  • Introduction to solid-state imaging techniques (IR, Raman, TOF-SIMS).

    • Main Results:

    • Solid-state spectroscopy techniques are versatile for characterizing active pharmaceutical ingredients, excipients, mixtures, and dosage forms.
    • IR, Raman, and solid-state NMR provide valuable insights into the physical properties of pharmaceutical solids.
    • Imaging techniques enhance spatial analysis of pharmaceutical materials.

    Conclusions:

    • Solid-state spectroscopy is indispensable for comprehensive physical characterization in pharmaceutical development.
    • These techniques support the optimization of drug substance and product quality.
    • Further exploration of imaging methods can advance pharmaceutical analysis.