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Bronchiectasis in systemic sclerosis. A study using high resolution computed tomography.

A P Andonopoulos¹, S Yarmenitis, P Georgiou

¹Department of Medicine, Division of Rheumatology, University of Patras School of Medicine, Patras, Greece.

Clinical and Experimental Rheumatology

|May 1, 2001

Summary

Systemic sclerosis (SSc) is significantly associated with bronchiectasis, a finding supported by high-resolution computed tomography (HRCT) in this study. Bronchiectasis should be recognized as a pulmonary manifestation of SSc.

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Area of Science:

Pulmonary Medicine
Rheumatology
Radiology

Background:

Systemic sclerosis (SSc) is an autoimmune disease affecting connective tissues.
Pulmonary involvement is a major cause of morbidity and mortality in SSc.

Purpose of the Study:

To investigate the presence of bronchiectasis in patients with SSc using high-resolution computed tomography (HRCT).
To determine if bronchiectasis is a pulmonary manifestation of SSc.

Main Methods:

Twenty-two SSc patients underwent pulmonary function testing and HRCT.
Statistical analysis included chi-square, Fisher's exact, and t-tests.

Main Results:

HRCT revealed ground glass in 68.2%, fibrosis in 40.9%, and cylindrical bronchiectasis in 59.1% of patients.

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Bronchiectasis was more frequent in diffuse SSc but not statistically significant.

Bronchiectasis showed no correlation with DLCO, ground glass, fibrosis, age, or disease duration.

Conclusions:

This study suggests a significant association between SSc and bronchiectasis.
Bronchiectasis should be considered a pulmonary manifestation of SSc.
SSc should be considered a condition that can cause bronchiectasis.