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Fibromyalgia syndrome and serotonin
1Division of Rheumatology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA. Muyessera@hotmail.com
Clinical and Experimental Rheumatology
|May 1, 2001
Summary
Serotonin
Area of Science:
- Neuroscience
- Pain Medicine
- Biochemistry
Background:
- Fibromyalgia syndrome (FMS) pathophysiology involves musculoskeletal, neuroendocrine, and central nervous system (CNS) disturbances.
- The exact etiopathogenesis of FMS remains unclear.
- Disturbances in serotonin metabolism and transmission are hypothesized in FMS.
Purpose of the Study:
- To review published studies on the pathophysiological role of serotonin in fibromyalgia syndrome.
- To assess the current understanding of serotonin's involvement in FMS.
Main Methods:
- Review of published studies on serotonin metabolism and transmission in FMS.
- Indirect measurement of serotonin function in the CNS of FMS patients.
Main Results:
- Studies indirectly measuring CNS serotonin function in FMS showed some abnormalities.
- Abnormalities were observed in both serotonin metabolism and transmission.
- The precise role of serotonin in FMS pathophysiology is not definitively established.
Conclusions:
- Current evidence suggests potential abnormalities in serotonin pathways in FMS.
- The role of serotonin in fibromyalgia syndrome's pathophysiology remains inconclusive.
- Further research is necessary to elucidate serotonin's exact role in FMS.
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