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Related Experiment Videos

External quality control program for inter-laboratory quality control.

N Bewarder1, P Müller

  • 1BIOREF GmbH, Dammweg 1, D-63776, Mömbris, Germany.

Anticancer Research
|May 1, 2001
PubMed
Summary
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External quality control for tumor marker testing revealed significant inter-laboratory variations, highlighting the need for improved accuracy and precision in diagnostic labs. This program aids in identifying and rectifying issues in tumor marker test performance.

Area of Science:

  • Clinical chemistry
  • Laboratory diagnostics
  • Quality control

Background:

  • Accurate and precise tumor marker testing is crucial for clinical decision-making.
  • Effective quality control (QC) procedures are essential in diagnostic laboratories.
  • External QC programs can enhance the reliability of laboratory test results.

Purpose of the Study:

  • To evaluate the effectiveness of an external quality control program for tumor marker testing.
  • To assess inter-laboratory variability in tumor marker test results.
  • To identify areas for improvement in laboratory test performance.

Main Methods:

  • Laboratories utilized BIOREF reference material for routine internal QC.
  • Monthly QC results were submitted for statistical analysis and inter-laboratory comparison.

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  • Comparison focused on accuracy and precision of tumor marker assays.

    • Main Results:

    • Significant variations in mean test results were observed between laboratories, particularly with different test kits.
    • Laboratories using the same test kit showed better correlation, but coefficient of variation discrepancies persisted.
    • The external QC program identified issues with accuracy and precision in individual laboratories.

    Conclusions:

    • External quality control effectively highlights problems in tumor marker test accuracy and precision.
    • The program provides a basis for improving diagnostic laboratory test performance.
    • Standardization of test kits and methods is important for reducing inter-laboratory variability.