[Model-based study of time-dependent coronary blood flow distribution in left ventricular wall and its dependences on...

The proposed model is of use for understanding the mechanism of intramyocardial circulation. There are three classical myocardial vascular nets in the model; each net has four vessel-size compartments which are characterized by time-dependent nonlinear resistance and compliance. The experimentally measured timed-varying perfusion and left ventricular pressure sources are used as driving inputs for the circulation. The phasic coronary blood flow characteristics predicted by the model exhibit waveform patterns that correlate qualitatively with the generally accepted results. In addition, more work is made about the myocardial infusion which is essentially controlled by the coronary pressure driving force. The results make it clear that the Intra-aortic balloon pumping and External counterpulsation are conducive to the balance between supply and demand of coronary blood flow.