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[Effect of mifepristone on cell-cycle kinetics of human placental chorio-trophoblastic and decidual cell]
Objective:
To study the effects of mifepristone on cell-cycle kinetics of human placental chorio-trophoblastic and decidual cells.
Methods:
Flow-cytometry was introduced in the study of the mechanism of early pregnancy terminating drug, mifepristone. Twenty-three samples were obtained from normal pregnant women by surgical aspiration. Another 24 samples were obtained in women pretreated with 150 mg mifepristone 48 hours before operation.
Results:
The percentage of the cytotrophoblastic cells in G0 + G1 phases was much higher in the treatment group (P < 0.01), whereas it was much lower (P < 0.01) in G2 + M phases, and the proliferating index of cells was significantly decreased. Apart from the increasing of decidual cells in G2 + M phases (P < 0.05), there was no change in other phases.
Conclusions:
Mifepristone may block the transformation of the cytotrophoblastic cells from G0, G1 phases to S phase, thus leading to the block of the proliferation of cells. Mifepristone has much more significant effects on the chorionic villi than on the decidua.
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