[Bases of safe substance levels for unified sanitary standards]

The study was undertaken to detect substances whose threshold and safe levels cannot be used without their correction in order to provide unified sanitary standardization. The criteria for choosing the substances were their high stability, capacity of bioaccumulation, the presence of mutagenic and/or carcinogenic properties and great discrepancy between the values of chronic toxicity of a substance and structure-activity relationships, which are typical of the structural series it belongs to. The use of these criteria may identify 155 substances standardized in water and 126 in the ambient air, whose threshold and safe levels in their oral and inhaled administrations are to be clarified.