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Value of MIB-1 labelling index (LI) in gliomas and its correlation with other prognostic factors. A clinicopathologic
C Rodríguez-Pereira1, J M Suárez-Peñaranda, M Vázquez-Salvado
1Department of Pathology Hospital General de Castellón, Spain. apimljsp@usc.es
Background:
In recent years, the monoclonal antibody MIB-1 has become the main factor to measure the proliferative potential of glial tumors. This antibody is equivalent to Ki-67, which is used in frozen sections, and reacts with a nuclear protein that is expressed through the cell cycle. We have investigated the value of MIB-1 Labelling Index (LI) as an independent prognostic factor in gliomas and its relationship with clinical and pathological parameters.
Methods:
MIB-1 LI was determined in 139 gliomas by using the Streptavidin-Biotin Complex (SBC) immunohistochemical method. MIB-1 LI immunoreactivity was measured with an automatic cell counting system. Survival was studied by using the Kaplan-Meier bivariant analysis and Cox multivariant regression.
Results:
In bivariant analysis MIB-1 LI increased with age, histological grade and a supratentorial lateral location. Only size and tumor grade were significant in Cox regression.
Conclusions:
Perhaps this proliferation marker is influenced by many factors which reduce its value as an isolated prognostic parameter.