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A simultaneous multichannel monophasic action potential electrode array for in vivo epicardial repolarization
A V Sahakian1, M S Peterson, S Shkurovich
1Department of Electrical and Computer Engineering, Northwestern University, Evanston, IL 60208, USA. sahakian@delta.ece.nwu.edu
IEEE Transactions on Bio-Medical Engineering
|May 1, 2001
Summary
This study introduces a novel multichannel electrode array for simultaneously recording monophasic action potentials (MAPs) from multiple epicardial sites in vivo. The device enables detailed in vivo epicardial repolarization mapping with high spatial resolution.
Area of Science:
- Cardiovascular Physiology
- Biomedical Engineering
- Electrophysiology
Background:
- Extracellular monophasic action potentials (MAPs) recording from single epicardial or endocardial sites has a long history.
- Simultaneous in vivo MAP recording from a large number of sites has not been previously achieved.
Purpose of the Study:
- To design and validate a novel multichannel electrode array for simultaneous in vivo epicardial MAP recording.
- To assess the array's capability in capturing depolarization and repolarization dynamics across multiple sites.
Main Methods:
- Development of a 16-electrode Ag-AgCl array with individual suspensions for controlled pressure.
- Testing the array in anesthetized open-chested pigs, recording MAPs from up to 16 ventricular sites.
- Evaluating the array's ability to detect local repolarization differences during AV junction pacing and induced ischemia.
Main Results:
- Simultaneous, diagnostic-quality MAP recordings were achieved from up to 13/16 ventricular sites.
- MAPs exhibited consistent morphology, stable baselines, and expected variations with pacing cycle length.
- The array successfully detected local repolarization changes during AV conduction and induced ischemia.
Conclusions:
- The simultaneous multichannel MAP electrode array is a viable tool for in vivo epicardial repolarization mapping.
- The array demonstrates potential for expansion to increase site density and spatial resolution for advanced cardiac mapping.