Evaluation of an optimal luteal phase support protocol in IVF

Area of Science:

• Reproductive Endocrinology
• In Vitro Fertilization (IVF)

Background:

• Luteal phase support is crucial in ovarian stimulation protocols, particularly the long protocol.
• Human chorionic gonadotropin (hCG) and progesterone are effective for luteal phase support, but hCG has a higher complication rate.

Purpose of the Study:

• To evaluate the efficacy and safety of different progesterone administration routes for luteal phase support.
• To compare vaginal progesterone administration with other methods, including intramuscular and oral routes.

Main Methods:

• Comparison of oral, intramuscular (i.m.), and vaginal progesterone administration routes.
• Assessment of progesterone's effectiveness in downregulating uterine contractions.
• Evaluation of Crinone 8% Vaginal Gel for ease of use and reduced leakage.

Main Results:

• Oral progesterone has low bioavailability and potential side effects.
• Intramuscular progesterone is effective but painful and requires assistance.
• Vaginal progesterone achieves high uterine levels (first uterine pass effect) and is effective in downregulating contractions.
• Crinone 8% Vaginal Gel offers reduced leakage and convenient daily administration.

Conclusions:

• Vaginal progesterone is as effective as intramuscular progesterone and safer than hCG for luteal phase support.
• Vaginal progesterone should be the standard choice for luteal phase support.
• Crinone 8% Vaginal Gel presents a comfortable and effective option for vaginal progesterone administration in IVF cycles.