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Subclinical suspiciousness as a risk factor for depressive episodes.

E Messias1, B Kirkpatrick

  • 1Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore, Maryland 21228, USA.

Acta Psychiatrica Scandinavica
|May 1, 2001
PubMed
Summary

Subclinical suspiciousness and some delusion-like experiences increase the risk of developing new depressive episodes in the general population. Hallucination-like experiences did not predict subsequent depression risk.

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Area of Science:

  • Psychiatry
  • Epidemiology
  • Mental Health

Background:

  • Previous research links suspiciousness to depression in psychotic individuals.
  • The relationship between suspiciousness and depression in nonpsychotic populations remains less understood.

Purpose of the Study:

  • To investigate if subclinical suspiciousness predicts new major depressive episodes in nonpsychotic individuals.
  • To examine the association between delusion-like and hallucination-like experiences and subsequent depression risk.

Main Methods:

  • Utilized data from the longitudinal, population-based Epidemiological Catchment Area (ECA) study.
  • Employed baseline clinical and demographic data to predict 1-year onset of depression in subjects without psychotic symptoms.

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Main Results:

  • Subclinical suspiciousness significantly increased the risk of new depressive episodes, even after controlling for demographics.
  • Three types of subclinical delusion-like experiences were also associated with a higher risk of depression.
  • Subclinical hallucination-like experiences did not predict subsequent depression.

Conclusions:

  • Subclinical suspiciousness is a risk factor for depression in the general, nonpsychotic population.
  • Certain delusion-like experiences may also contribute to the risk of developing depression.