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Updated: Aug 9, 2026
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A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
Published on: May 22, 2019
Depression in stroke patients 7 years following stroke
1Department of Psychiatry, Rigshospitalet, Copenhagen, Denmark.
Acta Psychiatrica Scandinavica
|May 1, 2001
Summary
Seven years after stroke, depression remains common, affecting 20% of patients. Stroke survivors also reported increased mood swings and irritability compared to controls.
Area of Science:
- Neurology
- Psychiatry
- Clinical Psychology
Background:
- Post-stroke depression is a significant concern, yet long-term studies are limited.
- Previous research primarily focused on depression within the initial years following a stroke.
Purpose of the Study:
- To investigate the long-term frequency of depression in stroke patients, specifically many years after the initial event.
- To assess affective and cognitive changes in stroke survivors over a 7-year period.
Main Methods:
- Re-examined 99 stroke patients and 28 control subjects 7 years after an initial study on post-stroke depression.
- Utilized research diagnostic criteria for depression diagnosis and a battery of cognitive tests.
- Assessed subjective changes in memory, concentration, mood, irritability, and fatigue over the 7-year interval.
Main Results:
- Twenty percent of stroke patients met criteria for major or minor depression, versus 11% of controls.
- Stroke patients reported greater mood lability and irritability compared to controls.
- Depressed stroke patients showed more significant impairments in concentration and memory function than non-depressed stroke patients.
Conclusions:
- Affective symptoms, including depression, are prevalent among stroke patients even 7 years post-stroke.
- Long-term monitoring for depression and related symptoms is crucial for stroke survivors.
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