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Livedoid vasculitis responding to PUVA therapy.

J H Lee1, H J Choi, S M Kim

  • 1Department of Dermatology, Yonsei University College of Medicine, Seoul, South Korea.

International Journal of Dermatology
|May 1, 2001
PubMed
Summary
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Systemic psoralen plus UVA (PUVA) therapy effectively treated livedoid vasculitis, rapidly stopping new lesions and healing existing ones with minimal side effects.

Area of Science:

  • Dermatology
  • Photomedicine

Background:

  • Livedoid vasculitis is a chronic, painful leg disorder with obscure etiology and difficult treatment.
  • Characterized by reticulated, ulcerative lesions leading to atrophic scars.

Purpose of the Study:

  • To evaluate the clinical efficacy and side-effects of psoralen plus UVA (PUVA) therapy for livedoid vasculitis.

Main Methods:

  • Eight South Korean patients with livedoid vasculitis received systemic PUVA therapy with 8-methoxypsoralen (8-MOP) and UVA.
  • Treatment involved incremental UVA doses (starting at 4 J/cm2) administered 2-3 times weekly.
  • Treatment outcomes were assessed via photographic evaluation.

Main Results:

  • All patients achieved rapid cessation of new lesion formation (mean 3.6 weeks).

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  • Significant symptom relief and complete healing of primary lesions occurred (mean 5.9 and 10 weeks, respectively).
  • Patients tolerated PUVA therapy well, with no unacceptable side effects reported.

    • Conclusions:

    • Systemic PUVA therapy using 8-MOP demonstrates significant efficacy in treating livedoid vasculitis.
    • Further investigation is warranted to establish PUVA as an alternative treatment option.