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Advances in psoriasis treatment.

S Feldman1

  • 1Westwood-Squibb Center for Dermatology Research Wake Forest University School of Medicine Winston-Salem, NC, USA.

Dermatology Online Journal
|May 1, 2001
PubMed
Summary

Effective psoriasis treatment requires addressing physical and psychosocial needs. Strategies vary for localized and generalized forms, focusing on rapid control and long-term maintenance using targeted therapies.

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Area of Science:

  • Dermatology
  • Immunology
  • Pharmacology

Background:

  • Psoriasis is a chronic inflammatory skin condition significantly impacting patients' quality of life.
  • Effective management necessitates a comprehensive approach addressing both physical symptoms and psychosocial well-being.
  • Treatment strategies are often tailored based on disease classification, such as localized versus generalized forms.

Purpose of the Study:

  • To outline current treatment strategies for localized and generalized psoriasis.
  • To emphasize the importance of achieving rapid disease control and maintaining remission.
  • To review various therapeutic modalities and their roles in psoriasis management.

Main Methods:

  • Review of current clinical data and treatment guidelines for psoriasis.
  • Categorization of treatment approaches for localized and generalized disease presentations.
  • Evaluation of topical therapies, phototherapy, and systemic agents.

Main Results:

  • For localized psoriasis, combination therapy with topical corticosteroids and noncorticosteroids (calcipotriene or tazarotene) is recommended.
  • UVB phototherapy offers rapid control and long-term maintenance for generalized psoriasis.
  • Systemic agents like methotrexate, cyclosporine, hydroxyurea, and mycophenolate mofetil are effective for generalized disease, with specific indications for short-term or long-term use.

Conclusions:

  • Integrated treatment plans are crucial for managing psoriasis effectively.
  • Therapeutic choices should balance rapid symptom control with long-term disease management.
  • A range of topical, phototherapeutic, and systemic options are available to suit different psoriasis severities and patient needs.

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