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Activities of cholic acid-derived antimicrobial agents against multidrug-resistant bacteria
E J Schmidt1, J S Boswell, J P Walsh
1Department of Microbiology, Brigham Young University, Provo, UT 84602, USA.
The Journal of Antimicrobial Chemotherapy
|May 1, 2001
Abstract:
Cationic cholic acid derivatives displayed potent and broad-spectrum activity against multidrug-resistant Gram-negative and -positive bacteria. Specific examples were effective permeabilizers of the outer membranes of many strains of multidrug-resistant Gram-negative bacteria and sensitized these to hydrophobic antibiotics. We also prepared a new cholic acid derivative with improved apparent selectivity for prokaryote membranes.