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Moderate alcohol consumption and postprandial plasma lipids in men with different risks for coronary heart disease

H F Hendriks1, M R van Haaren, R Leenen

  • 1Department of Physiology, TNO Nutrition and Food Research, Zeist, The Netherlands. hendriks@voeding.tno.nl

Alcoholism, Clinical and Experimental Research
|May 1, 2001
PubMed

Insights

Moderate alcohol intake affects postprandial lipoprotein metabolism similarly in men with varying coronary heart disease (CHD) risk factors. This suggests alcohol

Area of Science:

  • Cardiovascular Science
  • Nutritional Science
  • Metabolic Science

Background:

  • Moderate alcohol consumption is linked to reduced coronary heart disease (CHD) risk.
  • Conflicting data exists on whether CHD protection is influenced by individual CHD risk profiles.
  • Understanding alcohol's metabolic effects is crucial for cardiovascular health.

Purpose of the Study:

  • To investigate the impact of moderate alcohol consumption on postprandial lipoprotein metabolism.
  • To compare these effects in healthy middle-aged men with differing coronary heart disease (CHD) risk factors (plasma lipids and BMI).

Main Methods:

  • A crossover study design was employed in two groups of healthy middle-aged men (lower and higher CHD risk factors).
  • Participants consumed moderate alcohol (35 g/day) or alcohol-free beer in a crossover manner.
  • Postprandial lipoprotein metabolism was assessed after acute alcohol intake following periods of abstinence and moderate consumption.

Main Results:

  • Moderate alcohol consumption altered postprandial plasma total cholesterol, total triglycerides, and HDL composition.
  • Alcohol-induced metabolic changes were consistent between men with lower and higher CHD risk profiles.
  • The postprandial response to alcohol did not significantly differ after abstinence compared to after a 4-week moderate consumption period.

Conclusions:

  • Men with varying coronary heart disease (CHD) risk profiles, but without pre-existing disease, exhibit similar postprandial lipid responses to moderate alcohol intake.
  • These findings suggest that the immediate metabolic effects of moderate alcohol on lipids are not significantly modulated by baseline CHD risk factors in healthy individuals.
Abstract

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