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Systemic GLP-2 levels do not limit adaptation after distal intestinal resection
D Topstad1, G Martin, D Sigalet
1Division of Pediatric General Surgery and GI Research Group, University of Calgary, Calgary, Alberta, Canada.
Journal of Pediatric Surgery
|May 1, 2001
Summary
Distal resection increased glucagon-like peptide 2 (GLP-2) levels and caused gut adaptation, but failed to restore nutrient absorption. Thus, GLP-2 levels do not limit adaptation after ileocecal resection.
Area of Science:
- Gastroenterology
- Endocrinology
- Surgical Research
Background:
- Glucagon-like peptide 2 (GLP-2) promotes small bowel growth.
- GLP-2 is produced by L cells in response to nutrients.
- Ileocecal resection impacts nutrient absorption and gut adaptation.
Purpose of the Study:
- To test if distal small bowel and cecal resection decrease GLP-2 levels.
- To determine if resection reduces gut adaptation.
- To investigate the role of GLP-2 in post-resection adaptation.
Main Methods:
- Male Sprague-Dawley rats underwent ileal transection (controls) or ileocecal resection.
- Jejunal remnant length was either 10 cm or 20 cm.
- Endpoints included weight, histology, 3-O-methylglucose absorption, and serum GLP-2.
Main Results:
- Resected groups showed increased villus height but decreased nutrient absorption.
- Animals with 10 cm jejunal remnant had continuous weight loss.
- Serum GLP-2 levels significantly increased in both resection groups post-surgery.
Conclusions:
- Ileocecal resection in rats leads to increased GLP-2 levels and morphologic adaptation.
- Despite adaptation, nutrient absorption and weight recovery were impaired.
- Systemic GLP-2 levels do not appear to limit adaptation after distal ileocecal resection.