Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Primary hyperoxaluria type 1 in Japan.

A Ichiyama1, T Oda, E Maeda-Nakai

  • 1First Department of Biochemistry, Hamamatsu University School of Medicine, 3600 Handa-cho, Hamamatsu, Shizuoka 431-3192, Japan. ichiyama@hama-med.ac.jp

Cell Biochemistry and Biophysics
|May 2, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Involvement of CCAAT/enhancer-binding protein in regulation of the rat serine:pyruvate/alanine:glyoxylate aminotransferase gene expression.

FEBS letters·2001
Same author

Peroxisomal and mitochondrial targeting of serine:pyruvate/alanine:glyoxylate aminotransferase in rat liver.

Cell biochemistry and biophysics·2001
Same author

Oxalate synthesis in mammals: properties and subcellular distribution of serine:pyruvate/alanine:glyoxylate aminotransferase in the liver.

Molecular urology·2001
Same author

Store depletion by caffeine/ryanodine activates capacitative Ca(2+) entry in nonexcitable A549 cells.

Journal of biochemistry·2000
Same author

Effect of erythromycin on ATP-induced intracellular calcium response in A549 cells.

American journal of physiology. Lung cellular and molecular physiology·2000
Same author

A spectrophotometric method for the determination of glycolate in urine and plasma with glycolate oxidase.

Journal of biochemistry·2000
Same journal

In Vitro and In Silico Assessment of Anticancer Activity of Venom-Derived and Biomimetic Neurotransmitter Inhibitor Pentapeptides.

Cell biochemistry and biophysics·2026
Same journal

Green Fabrication and Characterization of Copper Oxide Nanoparticles Using C. Gigantea Leaf Extract and Their ROS-Mediated Anticancer Activity Against A549 Lung Cancer Cells.

Cell biochemistry and biophysics·2026
Same journal

From Isoprene Units to Polyprenols and Dolichols: 70 Years of Polyisoprenoid Biosynthesis Research.

Cell biochemistry and biophysics·2026
Same journal

Therapeutic Insights into the Hepatoprotective Effect of Strobilanthes callosa.

Cell biochemistry and biophysics·2026
Same journal

The Dual Role of TGF-β and Hypoxia on MMP14-Mediated Invasion in PC3 Cells.

Cell biochemistry and biophysics·2026
Same journal

Microalgae-Mediated Synthesis of Gold Nanoparticles from Indonesian Chlorella vulgaris InaCC M205 with Potential Anticancer Properties for Biomedical Application.

Cell biochemistry and biophysics·2026
See all related articles

Primary hyperoxaluria type 1 (PH1) involves impaired serine:pyruvate/alanine:glyoxylate aminotransferase (SPT/AGT) function. Japanese PH1 patients exhibit milder symptoms, potentially linked to dietary habits influencing SPT/AGT localization.

Area of Science:

  • Biochemistry
  • Genetics
  • Metabolic Disorders

Background:

  • Glyoxylate is a key precursor to oxalate.
  • Impaired serine:pyruvate/alanine:glyoxylate aminotransferase (SPT/AGT) function leads to increased oxalate production, causing calcium oxalate urolithiasis and systemic oxalosis.
  • SPT/AGT exhibits species-specific organelle localization (mitochondria in carnivores, peroxisomes in herbivores and humans).

Purpose of the Study:

  • To investigate the clinical presentation of primary hyperoxaluria type 1 (PH1) in Japanese patients.
  • To explore potential factors contributing to observed differences in PH1 symptom severity between Japanese and Western populations.

Main Methods:

  • Laboratory examination of 8 Japanese primary hyperoxaluria cases.
  • Comparative analysis of SPT/AGT localization and its relation to dietary habits.

Related Experiment Videos

Main Results:

  • Japanese PH1 patients presented with symptoms that appeared milder compared to Western patients.
  • Dietary habits, particularly the preference for boiled greens among the older Japanese generation, were hypothesized as a contributing factor.

Conclusions:

  • The peroxisomal localization of SPT/AGT is crucial for herbivores to prevent excessive oxalate production, likely due to higher glycolate intake from plants.
  • Dietary factors, such as the consumption of cooked vegetables, may influence SPT/AGT localization or activity, potentially explaining milder PH1 symptoms in some Japanese individuals.