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Proximal stomach function in systemic sclerosis: relationship with autonomic nerve function.

P Iovino1, G Valentini, C Ciacci

  • 1Department of Medical and Surgery of Digestive Disease, Medical School, Federico 11 University, Naples Italy.

Digestive Diseases and Sciences
|May 2, 2001
PubMed
Summary
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Systemic sclerosis (SSc) patients show proximal stomach dysfunction linked to autonomic nerve issues. This study confirms motility disorders are common in SSc due to autonomic dysfunction.

Area of Science:

  • Gastroenterology
  • Rheumatology
  • Neuroscience

Background:

  • Gastrointestinal (GI) issues are common in systemic sclerosis (SSc).
  • Proximal stomach function and its regulation in SSc are understudied.
  • Early neural lesions are hypothesized as a cause of GI involvement in SSc.

Purpose of the Study:

  • To investigate proximal stomach function in SSc patients.
  • To explore the relationship between proximal stomach function and autonomic nerve function in SSc.

Main Methods:

  • Twenty SSc patients and 11 controls underwent proximal stomach function measurement using an electronic barostat.
  • Proximal stomach function was assessed with and without glucagon administration.
  • Autonomic nerve function was evaluated in all participants.

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Main Results:

  • No significant difference in gastric compliance between SSc patients and controls.
  • Significant differences in pressure-volume curves with and without glucagon.
  • A significant positive association between gastric compliance and autonomic nerve function (P < 0.05).
  • The change in gastric compliance with glucagon correlated significantly with autonomic function (P < 0.05).

Conclusions:

  • Proximal stomach function is significantly associated with autonomic nerve function in systemic sclerosis patients.
  • Findings support the link between GI motility disorders and autonomic dysfunction in SSc.