Related Experiment Videos
Trovafloxacin hepatotoxicity
D A Lazarczyk1, N S Goldstein, S C Gordon
1William Beaumont Hospital, Division of Gastroenterology-Hepatology, Royal Oak, Michigan 48073, USA.
Digestive Diseases and Sciences
|May 2, 2001
Abstract:
A 19-year-old woman was treated for recurrent sinusitis with oral trovafloxacin and developed acute hepatitis and peripheral eosinophilia, with hepatosplenomegaly and ascites. Laparoscopic liver biopsy showed extensive centrilobular hepatocyte necrosis, likely causing venooclusive disease-like signs and symptoms. Clinical and laboratory abnormalities resolved completely after prolonged treatment with steroids. The temporal relationship between trovafloxacin and the onset of hepatitis favors this drug as a culprit.