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Antiviral activity of fattiviracin FV-8 against human immunodeficiency virus type 1 (HIV-1)
E S Habib1, K Yokomizo, K Nagao
1Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Abstract:
A novel antiviral agent, fattiviracin FV-8, purified from the culture broth of Streptomyces microflavus strain No. 2445, showed potent antiviral activities against human immunodeficiency virus type 1 (HIV-1), herpes simplex virus type 1 (HSV-1), varicella-zoster virus (VZV), and influenza A and B viruses. The action mechanism of fattiviracin FV-8 against HIV-1 was examined. As a result, the agent was thought to act on HIV-1 particles directly without lysis of the particles, and it affords the inhibition of viral entry into the host cells.
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