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Cellular angiofibroma of the vulva
J E Lane1, A N Walker, E N Mullis
1Department of Surgery, Mercer University School of Medicine, Medical Center of Southern Georgia, Macon, GA 31207-0001, USA.
Gynecologic Oncology
|May 2, 2001
Summary
Cellular angiofibroma, a benign mesenchymal neoplasm, can occur in postmenopausal women. Complete surgical excision is curative, with no recurrence observed in this case.
Area of Science:
- Gynecologic Oncology
- Surgical Pathology
Background:
- Cellular angiofibroma is a benign mesenchymal neoplasm.
- Distinguishing it from aggressive lesions is crucial.
- Typically affects women of reproductive age.
Observation:
- A 77-year-old postmenopausal woman presented with a slow-growing vulvar mass.
- History of hysterectomy, oophorectomy, and estrogen replacement therapy.
- Surgical excision resulted in no recurrence at 1 year.
Findings:
- Histopathology confirmed cellular angiofibroma with hyalinized vessels and cellular stroma.
- Immunohistochemistry showed vimentin and CD34 positivity.
- Stromal cells expressed estrogen and progesterone receptors.
Implications:
- Cellular angiofibroma is a benign vulvar neoplasm.
- Differential diagnosis must exclude aggressive lesions like angiomyxoma.
- The role of estrogen therapy in tumor development requires further investigation.