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Updated: Oct 7, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Tolerance during sedation in a pediatric ICU patient: effects on the BIS monitor
1Department of Child Health, The Division of Pediatric Critical Care/Pediatric Anesthesiology, The University of Missouri, Columbia, MO 65212, USA. Joseph_Tobias@muccmail.missouri.edu
Abstract:
The authors demonstrate the effects of tolerance as measured using the bispectral index (BIS) monitor. Over a 5-day period, there was a twofold increase in the dose of midazolam and a threefold increase in the dose of fentanyl required to provide the same level of sedation and the same BIS number in a 9 year old boy receiving sedation during mechanical ventilation.
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