Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Variations in urinary iodine excretion and thyroid function. A 1-year study in healthy men.

S Andersen1, K M Pedersen, I B Pedersen

  • 1Department of Endocrinology and Medicine, Aalborg Hospital, Reberbansgade, DK-9000 Aalborg, Denmark. stiga@dadlnet.dk

European Journal of Endocrinology
|May 2, 2001
PubMed
Summary

Urinary iodine levels can fluctuate daily, potentially misrepresenting iodine deficiency. Using 24-hour urinary iodine excretion estimates reduces variability and provides a more accurate population assessment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Similar quality of life after balloon pulmonary angioplasty or pulmonary endarterectomy for CTEPH.

JHLT open·2025
Same author

Fracture risk revisited: Bone mineral density T-score and fracture risk in type 2 diabetes.

Diabetes, obesity & metabolism·2024
Same author

The impact of pre-ictal statin use on vasospasm and outcome in aneurysmal subarachnoid hemorrhage.

Acta neurochirurgica·2023
Same author

Machine learning-based immune phenotypes correlate with STK11/KEAP1 co-mutations and prognosis in resectable NSCLC: a sub-study of the TNM-I trial.

Annals of oncology : official journal of the European Society for Medical Oncology·2023
Same author

From a teacher and school leader perspective: What happened with smoking rules and practices during a three-year smoking preventive intervention? - Findings from the X:IT II study.

Evaluation and program planning·2023
Same author

A robust experimental and computational analysis framework at multiple resolutions, modalities and coverages.

Frontiers in immunology·2022

Area of Science:

  • Endocrinology
  • Nutritional Science
  • Public Health

Background:

  • Assessing population iodine intake relies on cross-sectional studies.
  • Urinary iodine concentration (UIC) is a common biomarker.
  • Daily variations in urinary iodine can lead to misinterpretation of iodine deficiency.

Purpose of the Study:

  • To evaluate the impact of daily fluctuations on iodine status assessment.
  • To compare the accuracy of single spot urine samples versus 24-hour collections.
  • To investigate the relationship between iodine intake and thyroid function markers.

Main Methods:

  • A longitudinal study involving 16 healthy men in an iodine-deficient area.
  • Monthly measurements of urinary iodine and creatinine.

Related Experiment Videos

  • Analysis of serum thyroid-stimulating hormone (TSH), thyroxine (T4), and tri-iodothyronine (T3) over one year.

    • Main Results:

    • Average urinary iodine excretion was 57.0 µg/l (49.1 µg/24h).
    • Individual samples showed significant variation (10-260 µg/l), with 6.7% below 25 µg/l.
    • Estimated 24-hour urinary iodine excretion reduced variability by 24% compared to UIC.
    • Correlation between iodine excretion and TSH differed based on deficiency severity.

    Conclusions:

    • A small fraction of individual samples may falsely indicate severe iodine deficiency.
    • Estimated 24-hour urinary iodine excretion is a more reliable measure than spot UIC.
    • Moderate iodine deficiency (25-50 µg/24h) impacts thyroid hormone synthesis, unlike mild deficiency (50-100 µg/24h).