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Related Experiment Videos

High-fidelity transmission acquired via a developmental decrease in NMDA receptor expression at an auditory synapse.

K Futai1, M Okada, K Matsuyama

  • 1Department of Neurophysiology, University of Tokyo Faculty of Medicine, Tokyo 113-0033, Japan.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|May 23, 2001
PubMed
Summary

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Auditory synapse development improves high-frequency sound processing. Blocking NMDA receptors or reducing auditory activity in young mice impairs this crucial synaptic maturation for accurate sound localization.

Area of Science:

  • Neuroscience
  • Auditory System Development
  • Synaptic Plasticity

Background:

  • Central auditory relay synapses are crucial for sound localization.
  • Immature auditory synapses exhibit imprecise high-frequency transmission due to slow synaptic potentials.
  • This imprecision can lead to aberrant neural firing or blocked action potentials.

Purpose of the Study:

  • To investigate the developmental mechanisms underlying high-fidelity synaptic transmission in the auditory brainstem.
  • To understand the role of NMDA receptors and auditory activity in synaptic maturation.
  • To elucidate how precise one-to-one transmission is established for high-frequency inputs.

Main Methods:

  • Electrophysiological recordings in immature and mature mice.

Related Experiment Videos

  • Pharmacological manipulation using d(-)2-amino-5-phosphonovaleric acid (d-APV) to block NMDA receptors.
  • Bilateral cochlear ablations at postnatal day 7 (P7) to assess the impact of auditory activity.

    • Main Results:

    • Synaptic potentials shorten during maturation, with reduced NMDA receptor contributions, enabling precise transmission.
    • Experimental blockade of NMDA receptors in immature mice mimicked mature synaptic function.
    • Early cochlear ablation prevented the developmental decrease in NMDA receptor expression and high-fidelity transmission acquisition.

    Conclusions:

    • Auditory activity, starting around postnatal days 10-12, downregulates postsynaptic NMDA receptor expression.
    • This downregulation is critical for establishing high-fidelity synaptic transmission necessary for accurate sound localization.
    • NMDA receptor activity plays a key role in the developmental trajectory of auditory synapse function.